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EBV Mutation Detail Information

> R594K Search Result


Mutation Information
Mutation Site R594K
Mutation Type Amino acid level
Gene/Protein/Region Type EBNA1
Literature Information
PubMed PMID 28077791
Published Year 2017
Journal Oncotarget
Title Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.
Author Dheekollu J,Malecka K,Wiedmer A,Delecluse HJ,Chiang AK,Altieri DC,Messick TE,Lieberman PM
Evidence Amino acids A487V, T585I, T502N, D499E, and R594K are on the exposed EBNA1 surface opposite the DNA binding interface, suggesting that they may alter potential interactions of EBNA1 with other proteins. Amino acids T524I, I528V, and L533I are buried within the protein surface and have no apparent effect on overall structure.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation