HIV Mutation Detail Information

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Mutation Information

Mutation Site	R476K
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Genotype/Subtype	B
Viral Reference	AF038399.1
Immune Escape	Y
Country	Montreal and canda

Literature Information

PubMed PMID	32457241
Disease	HIV infection/AIDS
Published Year	2020
Journal	mBio
Title	The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Author	Prévost J,Tolbert WD,Medjahed H,Sherburn RT,Madani N,Zoubchenok D,Gendron-Lepage G,Gaffney AE,Grenier MC,Kirk S,Vergara N,Han C,Mann BT,Chénine AL,Ahmed A,Chaiken I,Kirchhoff F,Hahn BH,Haim H,Abrams CF,Smith AB 3rd,Sodroski J,Pazgier M,Finzi A
Evidence	We replaced HIV-1 consensus inner domain residues in the clade B HIV-1YU2 Env with the residues that specifically coevolved with H375 in CRF01_AE strains (Y61H, H105Q, I108V, D474N, M475I, R476K).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation