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Mutation Information
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Mutation Site
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R476A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp120 |
Literature Information
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PubMed PMID
|
23011758
|
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Published Year
|
2013 |
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Journal
|
Proteins |
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Title
|
HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. |
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Author
|
Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I |
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Evidence
|
Of the remaining mutants, E370A’s dissociation constant (KD) for KR21-αbt was 5-fold higher than that of WT, while V255A, M475A and R476A’s were 2, 4 and 3-fold higher, respectively (Table I).
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HIV Mutation Detail Information