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Mutation Information
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Mutation Site
|
R45K |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpu |
Literature Information
|
PubMed PMID
|
32665270
|
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Published Year
|
2020 |
|
Journal
|
mBio |
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Title
|
Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. |
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Author
|
Hopfensperger K,Richard J,Stürzel CM,Bibollet-Ruche F,Apps R,Leoz M,Plantier JC,Hahn BH,Finzi A,Kirchhoff F,Sauter D |
|
Evidence
|
Furthermore, the previously described R45K and R50K mutations known to selectively abrogate the ability of Vpu to inhibit NF-κB (39) had no significant effect on HLA-C mRNA levels (Fig. 2D) but resulted in increased NF-κB-driven expression of the IFNB gene (Fig. 2E).
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HIV Mutation Detail Information