HIV Mutation Detail Information

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Mutation Information
Mutation Site R45K
Mutation Type Amino acid level
Gene/Protein/Region Type Vpu
Genotype/Subtype B
Literature Information
PubMed PMID 30717826
Published Year 2019
Journal eLife
Title HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses.
Author Langer S,Hammer C,Hopfensperger K,Klein L,Hotter D,De Jesus PD,Herbert KM,Pache L,Smith N,van der Merwe JA,Chanda SK,Fellay J,Kirchhoff F,Sauter D
Evidence In order to abrogate IkappaB stabilization and NF-kappaB inhibition downstream of tetherin, a previously described cytoplasmic arginine residue within Vpu was mutated to lysine (R45K in subtype B, R50K in subtype C).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation