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Mutation Information
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Mutation Site
|
R45K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpu |
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Genotype/Subtype
|
B |
Literature Information
|
PubMed PMID
|
30717826
|
|
Published Year
|
2019 |
|
Journal
|
eLife |
|
Title
|
HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses. |
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Author
|
Langer S,Hammer C,Hopfensperger K,Klein L,Hotter D,De Jesus PD,Herbert KM,Pache L,Smith N,van der Merwe JA,Chanda SK,Fellay J,Kirchhoff F,Sauter D |
|
Evidence
|
In order to abrogate IkappaB stabilization and NF-kappaB inhibition downstream of tetherin, a previously described cytoplasmic arginine residue within Vpu was mutated to lysine (R45K in subtype B, R50K in subtype C).
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HIV Mutation Detail Information