|
Mutation Information
|
Mutation Site
|
R458K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Genotype/Subtype
|
adw2 |
Literature Information
|
PubMed PMID
|
10385663
|
|
Disease
|
HBV infection
|
|
Published Year
|
1999 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. |
|
Author
|
Tillmann HL,Trautwein C,Bock T,Böker KH,Jäckel E,Glowienka M,Oldhafer K,Bruns I,Gauthier J,Condreay LD,Raab HR,Manns MP |
|
Evidence
|
The mutations selected in the nonresponder (NR21) con-tained sequence changes outside the domain B of the HBV-DNA polymerase (N424K, R458K, N466D, S567A), and only1mutation(N424K) was located in thedomain A as shown inTable 9.
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|
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HBV Mutation Detail Information