Home
Virus
Gene
Disease
Dataset
Download
Help
 
HIV Mutation Detail Information

> R448A Search Result


Mutation Information
Mutation Site R448A
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Literature Information
PubMed PMID 33715562
Published Year 2021
Journal Journal of enzyme inhibition and medicinal chemistry
Title Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase-associated RNase H function.
Author Fois B,Corona A,Tramontano E,Distinto S,Maccioni E,Meleddu R,Caboni P,Floris C,Cottiglia F
Evidence Conversely, flavuglaucin B showed a significant loss in potency in the case of R448A (5.5-fold), R557A (6.5-fold) and, especially, A508V that totally impaired the RNase H inhibition by flavuglaucin B (IC50 >100 microM).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation