HIV Mutation Detail Information

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Mutation Information

Mutation Site	R448A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	32640577
Published Year	2020
Journal	Viruses
Title	Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants.
Author	Corona A,Ballana E,Distinto S,Rogolino D,Del Vecchio C,Carcelli M,Badia R,Riveira-Muñoz E,Esposito F,Parolin C,Esté JA,Grandi N,Tramontano E
Evidence	Hence, the single point mutations R448A, Q475A and R557A were independently introduced in the HIV-1 pol and mutant R448A-, Q475A- and R557A-RT were expressed and purified.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation