HIV Mutation Detail Information

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Mutation Information

Mutation Site	R440E
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Country	America

Literature Information

PubMed PMID	25174000
Published Year	2014
Journal	Nature chemical biology
Title	A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
Author	Herschhorn A,Gu C,Espy N,Richard J,Finzi A,Sodroski JG
Evidence	Of note, 18A inhibited infection of Cf2Th-CD4/CXCR4 cells by the chimeric YU2(HXV3+R440E) virus with an IC50 similar to that of the parental R5 YU2 virus infecting Cf2Th-CD4/CCR5 cells;therefore, infection of CXCR4-expressing cells by X4 viruses is not necessarily less sensitive to 18A inhibition than infection of CCR5-expressing cells by R5 viruses.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation