HIV Mutation Detail Information

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Mutation Information

Mutation Site	R405E
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	25383358
Published Year	2014
Journal	Molecular therapy. Methods & clinical development
Title	Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.
Author	Wang H,Shun MC,Li X,Di Nunzio F,Hare S,Cherepanov P,Engelman A
Evidence	Alteration of LEDGF/p75 residues Lys401, Lys402, and Arg405 to glutamates (K401E/K402E/R405E, referred to as EEE) reduced WT HIV-Luc infection by approximately fivefold, yet boosted the activity of the weakly infectious reverse-charge KK (E10K/E13K) HIV-1 IN mutant virus by approximately sixfold (from ~2% with WT LEDGF/p75 to ~13% with EEE).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation