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Mutation Information
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Mutation Site
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R315Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp120 |
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Genotype/Subtype
|
B |
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Immune Escape
|
Y |
Literature Information
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PubMed PMID
|
32470085
|
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Published Year
|
2020 |
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Journal
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PloS one |
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Title
|
Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens. |
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Author
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Li SW,Wright M,Healey JF,Hutchinson JM,O'Rourke S,Mesa KA,Lollar P,Berman PW |
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Evidence
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While the R315Q mutation prevents the elicitation of antibodies dependent on arginine such as the neutralizing mAb 447-52D, it does not affect elicitation of antibodies to the V3 stem such as PGT128 or PGT121.
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HIV Mutation Detail Information