HIV Mutation Detail Information

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Mutation Information

Mutation Site	R315Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Country	America

Literature Information

PubMed PMID	29672607
Disease	HIV infection/AIDS
Published Year	2018
Journal	PLoS pathogens
Title	Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.
Author	Kumar A,Smith CEP,Giorgi EE,Eudailey J,Martinez DR,Yusim K,Douglas AO,Stamper L,McGuire E,LaBranche CC,Montefiori DC,Fouda GG,Gao F,Permar SR
Evidence	We examined the highly variable N and C-terminal region amino acid residues K305Q, I307T, H308T, R315Q, F317L, A319T, and D322R (Fig 7), 3 of which (K305Q, I307T, and H308T) have previously been identified critical targets of the V3-specific IgG responses associated with reduced MTCT risk.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation