HIV Mutation Detail Information

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Mutation Information

Mutation Site	R308L
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	29222332
Published Year	2018
Journal	The Journal of biological chemistry
Title	Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.
Author	de Taeye SW,de la Peña AT,Vecchione A,Scutigliani E,Sliepen K,Burger JA,van der Woude P,Schorcht A,Schermer EE,van Gils MJ,LaBranche CC,Montefiori DC,Wilson IA,Moore JP,Ward AB,Sanders RW
Evidence	Together, these modifications further stabilized the resulting SOSIP.v5.2 S306L/R308L trimers in the prefusion state in which V3 is sequestered.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation