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Mutation Information
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Mutation Site
|
R277K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
3'-azido-2',3'-dideoxyguanosine (3'-azido-ddG) |
Literature Information
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PubMed PMID
|
24211331
|
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Published Year
|
2014 |
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Journal
|
Antiviral research |
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Title
|
Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine. |
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Author
|
Meteer JD,Schinazi RF,Mellors JW,Sluis-Cremer N |
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Evidence
|
In this study, we have defined the molecular mechanisms of 3’-azido-ddG resistance by performing in-depth biochemical analyses of HIV-1 RT containing mutations L74V, F77L, V106I, L214F, R277K and K476N (SGS3).
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HIV Mutation Detail Information