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Mutation Information
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Mutation Site
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R269K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
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Country
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Africa |
Literature Information
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PubMed PMID
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30891603
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Disease
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HIV infection/AIDS
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Published Year
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2019 |
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Journal
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The Journal of antimicrobial chemotherapy |
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Title
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High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO. |
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Author
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Mboumba Bouassa RS,Mossoro-Kpinde CD,Gody JC,Veyer D,Péré H,Matta M,Robin L,Grésenguet G,Charpentier C,Bélec L |
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Evidence
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The asterisk indicates polymorphic mutations occurring at <20% in the integrase gene [E96D, I203M, N254K and V260I (16.6%), A265V, D232N, D270H, G106A/K, K219N, R269K and V165I (11.1%), A23V, D116N, D229E, D253H, D279N, E85K, E157K, E170K, E198D/E, E212L, F181L, G70R, G82E, G136R, G149R, G247E, I60M, I200L, I220L, I268I/L, K14R, K111T, K173R, K186R, K188R, K236Q, K240E, M154I, P238G, Q221S/T, R107K, R166K, R224Q, S195T, S283G, V31I, V110I and Y227F (5.5%)].
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HIV Mutation Detail Information