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Mutation Information
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Mutation Site
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R269A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
Literature Information
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PubMed PMID
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32960169
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Published Year
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2020 |
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Journal
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eLife |
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Title
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Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. |
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Author
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Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB |
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Evidence
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We and others have recently shown that premature loss of the viral genome and IN, as well as spatial separation of RT from vRNPs, may underlie the reverse transcription defect observed in eccentric viruses generated in the presence of ALLINIs or the class II IN R269A/K273A substitutions.
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HIV Mutation Detail Information