HIV Mutation Detail Information

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Mutation Information
Mutation Site R264K
Mutation Type Amino acid level
Gene/Protein/Region Type CA
Combined Mutation ca.R264K+ca.L268M;ca.R264K+ca.R286K+ca.T280S
Genotype/Subtype B
Immune Escape Y
Literature Information
PubMed PMID 11157057
Clinical information Yes
Disease HIV infection/AIDS
Published Year 2001
Journal The Journal of experimental medicine
Title Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.
Author Kelleher AD,Long C,Holmes EC,Allen RL,Wilson J,Conlon C,Workman C,Shaunak S,Olson K,Goulder P,Brander C,Ogg G,Sullivan JS,Dyer W,Jones I,McMichael AJ,Rowland-Jones S,Phillips RE
Evidence Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation