HIV Mutation Detail Information

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Mutation Information

Mutation Site	R263K
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	33712691
Published Year	2021
Journal	Communications biology
Title	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Author	Pandey KK,Bera S,Shi K,Rau MJ,Oleru AV,Fitzpatrick JAJ,Engelman AN,Aihara H,Grandgenett DP
Evidence	Both purified RSV IN mutants were unable to form the octameric CSC while IN R263K was only capable of producing the tetrameric CSC suggesting that Arg263 in the distal IN dimer may play an important role in octameric intasome assembly (Supplementary Fig. 6b).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation