|
Mutation Information
|
Mutation Site
|
R263K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
INSTIs |
|
Country
|
Russia |
Literature Information
|
PubMed PMID
|
32752001
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs. |
|
Author
|
Kirichenko A,Lapovok I,Baryshev P,van de Vijver DAMC,van Kampen JJA,Boucher CAB,Paraskevis D,Kireev D |
|
Evidence
|
Two of the patients had major mutations, including R263K (1/183;0.5%), which was associated with intermediate-level DTG, EVG resistance, and low-level RAL, BIC resistance, and unusual mutation in DR-position S147T, which does not reduce susceptibility to any INSTI.
|
|
|
HIV Mutation Detail Information