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Mutation Information
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Mutation Site
|
R263K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
bictegravir (BIC);emtricitabine (FTC);tenofovir alafenamide (TAF);dolutegravir (DTG) |
Literature Information
|
PubMed PMID
|
32701823
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
|
Journal of acquired immune deficiency syndromes (1999) |
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Title
|
Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Dolutegravir (DTG)+F/TAF or DTG+F/Tenofovir Disoproxil Fumarate (TDF) in the Presence of Pre-existing NRTI Resistance. |
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Author
|
Acosta RK,Willkom M,Andreatta K,Liu H,Martin R,Parvangada A,Martin H,Collins S,White KL |
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Evidence
|
The most frequent substitution was T97A in 12 participants, followed by Y143H, N155H/S, and R263K in 2 participants each, and S147G in 1 participant.
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HIV Mutation Detail Information