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Mutation Information
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Mutation Site
|
R263K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
dolutegravir (DTG) |
Literature Information
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PubMed PMID
|
27539455
|
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Published Year
|
2016 |
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Journal
|
Infectious diseases and therapy |
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Title
|
New Antiretroviral Treatment for HIV. |
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Author
|
Badowski ME,Pérez SE,Biagi M,Littler JA |
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Evidence
|
Although the risk is low, a retrospective analysis performed in British Columbia documented three cases of dolutegravir resistance (two ART-experienced patients developed R263 K and one ART-naive patient developed T66I). Dolutegravir/lamivudine/abacavir is co-formulated as a STR given once daily and has been associated with an increased serum creatinine (SCr) secondary to inhibiting tubular secretion of creatinine, but glomerular function was unaffected.
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HIV Mutation Detail Information