HIV Mutation Detail Information

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Mutation Information

Mutation Site	R263A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	32960169
Published Year	2020
Journal	eLife
Title	Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author	Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence	By contrast, R262A/R263A and R269A/K273A substitutions within the CTD and the K34A change within the NTD did not perturb IN tetramer formation, and thus likely directly interfered with IN binding to RNA.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation