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Mutation Information
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Mutation Site
|
R262A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
mAb33 |
Literature Information
|
PubMed PMID
|
16790058
|
|
Published Year
|
2006 |
|
Journal
|
Retrovirology |
|
Title
|
Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody. |
|
Author
|
Ramcharan J,Colleluori DM,Merkel G,Andrake MD,Skalka AM |
|
Evidence
|
The non-epitope substitution R262A derivative binds mAb33 as well as the parental protein sIN, as expected from previous NMR studies, while W243A, which may be involved in dimer interactions, is compromised for antibody binding.
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HIV Mutation Detail Information