HPV Mutation Detail Information

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Mutation Information

Mutation Site	R25Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	L1
Amino acid_Mutation	G5503A
Genotype/Subtype	HPV18
Viral Reference	NC_001357.1
Country	China

Literature Information

PubMed PMID	23451059
Disease	Cervical carcinoma
Published Year	2013
Journal	PloS one
Title	Sequence variation analysis of HPV-18 isolates in southwest China.
Author	Shen M,Ding X,Li T,Chen G,Zhou X
Evidence	DNA sequence analysis of the HPV-18 L1 region revealed six variations: a G to A transition at nt5503, leading to a R25Q AA substitution (n = 23, 41.1%) (Fig. 1I); a C to G transversion at nt5701 with an AA change of P91R (n = 23, 41.1%) (Fig. 1J); a C to G transversion at nt6460 with an AA change of P344R (n = 24, 42.9%) (Fig. 1K); a C to G transversion at nt6625 with an AA change of P399R (n = 25, 44.6%) (Fig. 1L); a C to G transversion at nt6842 with an AA change of P471R (n = 23, 41.1%) (Fig. 1M); and G to A transition at nt6906 with an AA change of D493N (n = 12, 21.4%) (Fig. 1N).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation