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Mutation Information
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Mutation Site
|
R23A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vif |
|
Viral Reference
|
K03455.1
|
Literature Information
|
PubMed PMID
|
31665623
|
|
Published Year
|
2019 |
|
Journal
|
Cell reports |
|
Title
|
HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. |
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Author
|
Salamango DJ,Ikeda T,Moghadasi SA,Wang J,McCann JL,Serebrenik AA,Ebrahimi D,Jarvis MC,Brown WL,Harris RS |
|
Evidence
|
Moreover, at least 2 mutants, R23A and K36A, were partially functional for both activities (but not for A3G degradation), further indicating a cause-and-effect relationship.
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HIV Mutation Detail Information