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HIV Mutation Detail Information

> R199A Search Result


Mutation Information
Mutation Site R199A
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 32960169
Published Year 2020
Journal eLife
Title Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence We found that K14A, E96A, Y99A, K103A, V165A, R187A, K188E R199A, K236E, and R269A/R273A IN mutants trans-complemented a catalytically inactive IN at levels similar to the WT, whereas W108R, R228A, and V260E mutants were unable to do so (Figure 2D-E).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation