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Mutation Information
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Mutation Site
|
R18G |
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Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
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Viral Reference
|
K03455.1
|
Literature Information
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PubMed PMID
|
30862755
|
|
Published Year
|
2019 |
|
Journal
|
mBio |
|
Title
|
Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. |
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Author
|
Craveur P,Gres AT,Kirby KA,Liu D,Hammond JA,Deng Y,Forli S,Goodsell DS,Williamson JR,Sarafianos SG,Olson AJ |
|
Evidence
|
Notably, shortening the R18 side chain (R18G and R18A) should neither affect the overall structure of the CA protein nor impact its ability to form hexameric assemblies, since these are present in the observed morphologies.
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HIV Mutation Detail Information