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Mutation Information
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Mutation Site
|
R187K |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
BZLF1 |
Literature Information
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PubMed PMID
|
20808903
|
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Published Year
|
2010 |
|
Journal
|
PLoS pathogens |
|
Title
|
A subset of replication proteins enhances origin recognition and lytic replication by the Epstein-Barr virus ZEBRA protein. |
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Author
|
El-Guindy A,Heston L,Miller G |
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Evidence
|
A ZEBRA mutant, Z(S173A), at a phosphorylation site and three point mutants in the DNA recognition domain of ZEBRA, namely Z(Y180E), Z(R187K) and Z(K188A), were similarly deficient at activating lytic DNA replication and expression of late gene expression but were competent to activate transcription of viral early lytic genes.
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EBV Mutation Detail Information