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EBV Mutation Detail Information

> R183K Search Result


Mutation Information
Mutation Site R183K
Mutation Type Amino acid level
Gene/Protein/Region Type BZLF1
Literature Information
PubMed PMID 16940523
Published Year 2006
Journal Journal of virology
Title Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication.
Author Heston L,El-Guindy A,Countryman J,Dela Cruz C,Delecluse HJ,Miller G
Evidence A single acidic substitution at any one of the 9 basic amino acids destroyed DNA binding and the capacity of the mutant ZEBRA protein to activate lytic gene expression. Conservative substitutions in basic residues in three mutants, the R183K, R187K, and K188R proteins, did not affect DNA binding.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation