HIV Mutation Detail Information

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Mutation Information
Mutation Site R17A
Mutation Type Amino acid level
Gene/Protein/Region Type Vif
Combined Mutation vif.R17A+vif.M16A
Literature Information
PubMed PMID 28302150
Published Year 2017
Journal Retrovirology
Title Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.
Author Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK
Evidence Finally, we also observed that N3A-R4A, Q12A-V13A, M16A-R17A, N19A-T20A, and R23A-L24A mutants exhibited a significantly higher efficiency of binding to CBFbeta compared to WT Vif (Fig. 1b;values indicated in red);the potential biological significance of increased binding to CBFbeta by these mutants was not further examined in these studies.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation