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Mutation Information
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Mutation Site
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R178G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Nef |
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Country
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Netherlands |
Literature Information
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PubMed PMID
|
33800773
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Disease
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HIV infection/AIDS
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Published Year
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2021 |
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Journal
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Viruses |
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Title
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Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction. |
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Author
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Kruize Z,van Nuenen AC,van Wijk SW,Girigorie AF,van Dort KA,Booiman T,Kootstra NA |
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Evidence
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The change of charge in the protein interaction site (AA 12–39) and the presence of amino acids 12G, N51T, H116N and 188S in Nef were associated with a significant increased infectivity of Bal26-pseudotyped HIV-1 produced in the presence of SERINC3, while increased length of the protein interaction site (AA12–39), 9S, 43I and S163C also increased and 11P, 14A, V148X, 161N and R178G decreased infectivity, albeit not significantly (Figure 5A and Supplementary Table S2).
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HIV Mutation Detail Information