HBV Mutation Detail Information

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Mutation Information

Mutation Site	R169P
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Amino acid_Mutation	G660C
Genotype/Subtype	A
Immune Escape	Y

Literature Information

PubMed PMID	20881037
Published Year	2010
Journal	Journal of virology
Title	Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Author	Ito K,Qin Y,Guarnieri M,Garcia T,Kwei K,Mizokami M,Zhang J,Li J,Wands JR,Tong S
Evidence	Here we used transcomplementation assay to confirm that the I110M, G119E, and R169P mutations in the S domain of viral envelope proteins impair virion secretion and that an M133T mutation rescues virion secretion of the I110M and G119E mutants.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation