HBV Mutation Detail Information

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Mutation Information

Mutation Site	R169L
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	A

Literature Information

PubMed PMID	20881037
Published Year	2010
Journal	Journal of virology
Title	Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Author	Ito K,Qin Y,Guarnieri M,Garcia T,Kwei K,Mizokami M,Zhang J,Li J,Wands JR,Tong S
Evidence	Among the R169 mutants, the R169G and R169L mutants were similar to the R169P mutant in possessing little double-stranded replicative DNA and in being deficient in the secretion of both virions and HBsAg, whereas the R169H and R169Q mutants showed selective impairment or block of virion secretion (Fig. 2A, B, E, and F, lanes 10 to 14)

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation