HIV Mutation Detail Information

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Mutation Information

Mutation Site	R166G
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	HxB2
Country	France

Literature Information

PubMed PMID	33872329
Disease	HIV infection/AIDS
Published Year	2021
Journal	PLoS pathogens
Title	Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.
Author	Armani-Tourret M,Zhou Z,Gasser R,Staropoli I,Cantaloube-Ferrieu V,Benureau Y,Garcia-Perez J,Pérez-Olmeda M,Lorin V,Puissant-Lubrano B,Assoumou L,Delaugerre C,Lelièvre JD,Lévy Y,Mouquet H,Martin-Blondel G,Alcami J,Arenzana-Seisdedos F,Izopet J,Colin P,Lagane B
Evidence	F8 Env, in contrast to these other RES Envs, did not show improved resistance to the V2-apex bNAbs (Figs 3A and S3A and S3B), although it hosts several mutations of residues that have been reported to regulate their binding (N156K, R166G, K171E) (S3C Fig).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation