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Mutation Information
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Mutation Site
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R162A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BRLF1 |
Literature Information
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PubMed PMID
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19232420
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Published Year
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2009 |
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Journal
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Virology |
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Title
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Two phenylalanines in the C-terminus of Epstein-Barr virus Rta protein reciprocally modulate its DNA binding and transactivation function. |
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Author
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Chen LW,Raghavan V,Chang PJ,Shedd D,Heston L,Delecluse HJ,Miller G |
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Evidence
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HKB5/Cl8 cells were transfected with plasmids expressing wild-type FLAG-Rta, FLAG-Rta (F600A/F605A) and FLAG-Rta (R162A), a mutant of Rta that was deficient in binding to DNA by EMSA (data not shown). Chromatin extracts were immunoprecipitated with pre-immune serum or with antibodies to FLAG.
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EBV Mutation Detail Information