HBV Mutation Detail Information

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Mutation Information

Mutation Site	R127H
Mutation Type	Amino acid level
Gene/Protein/Region Type	C
Genotype/Subtype	A
Viral Reference	X02763
Country	Asia‐Pacific;Europe

Literature Information

PubMed PMID	32579776
Disease	Chronic hepatitis B
Published Year	2020
Journal	Journal of viral hepatitis
Title	Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
Author	Verbinnen T,Hodari M,Talloen W,Berke JM,Blue D,Yogaratnam J,Vandenbossche J,Shukla U,De Meyer S,Lenz O
Evidence	Baseline minority variants that reduce JNJ‐6379 in vitro activity were present in two JNJ‐6379‐treated patients: one 250 mg JNJ‐6379‐treated patient (patient ID #15, GT‐F, HBeAg‐negative; Figure 2D) carried the R127H minority variant (sequence‐read frequency of 1%; FC = 3.7) and showed HBV DNA decline from baseline at the end of treatment of 2.54 log10 IU/mL.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation