Mutation Information
Mutation Site
|
R118G |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Vpr |
Literature Information
PubMed PMID
|
32538781
|
Published Year
|
2020 |
Journal
|
eLife |
Title
|
HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. |
Author
|
Zhang F,Bieniasz PD |
Evidence
|
When the biotinylation proximity assay (Roux et al., 2012) was coupled to Western blot analysis, CCDC137 was found to be biotinylated by Vpr-BirA(R118G) but not BirA(R118G) despite our inability to detect biotinylated CCDC137 in the initial mass spectroscopic screens (Figure 3C).
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