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Mutation Information
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Mutation Site
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R10T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
|
28497579
|
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Published Year
|
2017 |
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Journal
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The Journal of pathology |
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Title
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Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch. |
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Author
|
Kranjec C,Holleywood C,Libert D,Griffin H,Mahmood R,Isaacson E,Doorbar J |
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Evidence
|
To further characterize the contribution of HPV‐16 E6 to the regulation of Notch, we repeated Notch mRNA and protein analysis in NIKS expressing either wild‐type HPV‐16 E6, a 16E6 mutant lacking the C‐terminal PDZ‐binding motif (ΔPBM), or the 16E6 R8S/P9A/R10T (SAT) mutant, which are unable to bind and degrade PDZ domain‐containing proteins and p53, respectively.
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HPV Mutation Detail Information