Mutation Information
Mutation Site
|
R10G |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
E6 |
Amino acid_Mutation
|
A131G |
Genotype/Subtype
|
HPV16 |
Viral Reference
|
NC_001526.1
|
Country
|
Sweden |
Literature Information
PubMed PMID
|
22558401
|
Disease
|
Squamous-cell carcinoma;
Head and neck carcinoma;
Cervical carcinoma
|
Published Year
|
2012 |
Journal
|
PloS one |
Title
|
Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden. |
Author
|
Du J,Nordfors C,Näsman A,Sobkowiak M,Romanitan M,Dalianis T,Ramqvist T |
Evidence
|
The rare E6 variant R10G was relatively frequent (19%) in TSCC, absent in CC and infrequent (4%) in CS, while the well-known L83V variant was common in TSCC (40%), CC (31%), and CS (29%). The difference for R10G was significant between TSCC and CC (p = 0.0003), as well as between TSCC and CS (p = 0.009).
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