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Mutation Information
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Mutation Site
|
R100D |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
BHRF1 |
Literature Information
|
PubMed PMID
|
31888174
|
|
Published Year
|
2019 |
|
Journal
|
Viruses |
|
Title
|
Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. |
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Author
|
Chen J,Kendrick S,Qin Z |
|
Evidence
|
Loss-of-function assays using BHRF1 mutants in EBV-infected B-cell lymphomas also supported its role in chemoresistance and indicated that BHRF1-mediated anti-apoptosis was associated with mutants of G99A, R100D, and F72W. The authors also found that one of the mutants, F72W, exhibited different effects on the response to etoposide and ionomycin.
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EBV Mutation Detail Information