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Mutation Information
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Mutation Site
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Q74P |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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EBNA1 |
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Viral Reference
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V01555.2
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Country
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Western Australian |
Literature Information
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PubMed PMID
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26849221
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Disease
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Multiple sclerosis
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Published Year
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2016 |
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Journal
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PloS one |
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Title
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Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis. |
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Author
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Tschochner M,Leary S,Cooper D,Strautins K,Chopra A,Clark H,Choo L,Dunn D,James I,Carroll WM,Kermode AG,Nolan D |
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Evidence
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N-terminal sequence analysis showed high conservation and identified only three different variants: 19 samples demonstrated 100% sequence similarity with the N terminal sequence of the EBV reference strain B95-8, while 12 sequences matched the previously identified type 2 EBV strain AG876 which differs to B95-8 in the positions: Q16E, E18G, D24E, S27G and A85T. Three of these positions (Q16E, E18G, S27G) have previously been described to occur in combination (44). The third variant occurred in seven samples and aligned well with AG876 but contained two mismatches to it: EBNA-1 amino acid positions: V70A), (Q74P.
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EBV Mutation Detail Information