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Mutation Information
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Mutation Site
|
Q69P |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E4 |
|
Amino acid_Mutation
|
A3537C |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Romania |
Literature Information
|
PubMed PMID
|
25143263
|
|
Disease
|
Cervical carcinoma;
Squamous-cell carcinoma;
Cervical intraepithelial neoplasia
|
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Published Year
|
2014 |
|
Journal
|
Archives of virology |
|
Title
|
Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients. |
|
Author
|
Plesa A,Anton G,Iancu IV,Diaconu CC,Huica I,Stanescu AD,Socolov D,Nistor E,Popa E,Stoian M,Botezatu A |
|
Evidence
|
Only silent mutations (positions 3361, 3386 and 3376) were detected in the N-terminal domain, while the C-terminal domain contained A3537C and T3565G missense mutations resulting in amino acid changes (Q69P and H78Q, respectively).
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HPV Mutation Detail Information