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Mutation Information
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Mutation Site
|
Q66P |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E6 |
|
Amino acid_Mutation
|
C279G |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Romania |
Literature Information
|
PubMed PMID
|
25143263
|
|
Disease
|
Cervical carcinoma;
Squamous-cell carcinoma;
Cervical intraepithelial neoplasia
|
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Published Year
|
2014 |
|
Journal
|
Archives of virology |
|
Title
|
Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients. |
|
Author
|
Plesa A,Anton G,Iancu IV,Diaconu CC,Huica I,Stanescu AD,Socolov D,Nistor E,Popa E,Stoian M,Botezatu A |
|
Evidence
|
The most prevalent missense mutations in HPV16 E6 (C279G, C285G, T288G, T295G, A296C, A305C, A306G, G328G, T350G) leading to amino acid changes (Q66P; A68G; V69G; D71E; K72Q; K75R; F76L; E82D; L90V) were found in 55 of 124 cases.
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HPV Mutation Detail Information