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Mutation Information
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Mutation Site
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Q662E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
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Country
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America |
Literature Information
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PubMed PMID
|
29672607
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Disease
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HIV infection/AIDS
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Published Year
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2018 |
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Journal
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PLoS pathogens |
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Title
|
Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. |
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Author
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Kumar A,Smith CEP,Giorgi EE,Eudailey J,Martinez DR,Yusim K,Douglas AO,Stamper L,McGuire E,LaBranche CC,Montefiori DC,Fouda GG,Gao F,Permar SR |
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Evidence
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To understand the role of amino acids at position 662 and 683 in resistance of infant T/F viruses against maternal plasma, two gp41 mutants R683K and Q662E were generated for 100997i and 102407i T/F env genes respectively.
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HIV Mutation Detail Information