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Mutation Information
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Mutation Site
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Q65R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
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Genotype/Subtype
|
G |
Literature Information
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PubMed PMID
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32753492
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Published Year
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2020 |
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Journal
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mBio |
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Title
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HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. |
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Author
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Li D,Lopez A,Sandoval C,Nichols Doyle R,Fregoso OI |
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Evidence
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In contrast to cell cycle arrest, only HIV-1 Q65R/HIV-2 Q70R Vpr lost the ability to damage DNA (Fig. 6B and Fig. S6C), indicating that damage of DNA occurs independently of cell cycle arrest and of the Vpr-host protein-protein interactions assayed here.
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HIV Mutation Detail Information