|
Mutation Information
|
Mutation Site
|
Q58E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Viral Reference
|
HXB2
|
|
Relevant Drug
|
PIs |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
33668946
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
Pathogens (Basel, Switzerland) |
|
Title
|
HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China. |
|
Author
|
Li M,Liang S,Zhou C,Chen M,Liang S,Liu C,Zuo Z,Liu L,Feng Y,Song C,Xing H,Ruan Y,Shao Y,Liao L |
|
Evidence
|
Drug resistance mutations (DRMs) were detected at 12 positions in the partial pol region by Sanger sequencing (Figure 1), including one in the protease (PR) region, an accessory protease inhibitor (PI)-related resistance mutation (Q58E), and eleven in the reverse transcriptase (RT) region, including one nucleotide reverse transcriptase inhibitor (NRTI)-related (M184V), and ten others were NNRTI-related.
|
|
|
HIV Mutation Detail Information