|
Mutation Information
|
Mutation Site
|
Q58E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
PIs |
Literature Information
|
PubMed PMID
|
33093566
|
|
Published Year
|
2020 |
|
Journal
|
Scientific reports |
|
Title
|
Nanoscale flow cytometry reveals interpatient variability in HIV protease activity that correlates with viral infectivity and identifies drug-resistant viruses. |
|
Author
|
Bonar MM,Tabler CO,Haqqani AA,Lapointe LE,Galiatsos JA,Joussef-Piña S,Quiñones-Mateu ME,Tilton JC |
|
Evidence
|
Virus 08-175 was found to have four major PI resistance mutations in PR: M46I, I54L, I84V, L90M and four accessory mutations: L10F, L33F, Q58E, and G73T and was predicted to have high-level resistance to all PIs except darunavir, to which it has intermediate resistance.
|
|
|
HIV Mutation Detail Information