HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q483L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RNase H
Country	South Africa

Literature Information

PubMed PMID	32071061
Disease	HIV infection/AIDS
Published Year	2020
Journal	Antimicrobial agents and chemotherapy
Title	Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.
Author	McCormick KD,Penrose KJ,Brumme CJ,Harrigan PR,Viana RV,Mellors JW,Parikh UM,Wallis CL
Evidence	Interestingly, three out of nine isolates with the RNase H domain mutations Q480H and Q483L (q < 0.18 and q < 0.18, respectively) had phenotypic FC values that exceeded the upper limit of the assay (>272 FC category; data not shown).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation