Mutation Information
Mutation Site
|
Q475A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
NNRTIs;efavirenz (EFV) |
Literature Information
PubMed PMID
|
32183488
|
Published Year
|
2020 |
Journal
|
Molecules (Basel, Switzerland) |
Title
|
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication. |
Author
|
Corona A,Onnis V,Del Vecchio C,Esposito F,Cheng YC,Tramontano E |
Evidence
|
Besides, both compounds were tested also on RTs mutated in two amino acid residues within the RNase H domain, Q475A and A502F, part of conserved regions of RNase H domain, that have been shown to be involved in the binding of RNase H inhibitors into a pocket close to the RNase H catalytic site but acting as allosteric RNase H inhibitors.
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