HBV Mutation Detail Information

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Mutation Information

Mutation Site	Q474H
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Genotype/Subtype	A

Literature Information

PubMed PMID	11050059
Clinical information	Yes
Disease	Chronic hepatitis B
Published Year	2000
Journal	Hepatology (Baltimore, Md.)
Title	Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B.
Author	Nafa S,Ahmed S,Tavan D,Pichoud C,Berby F,Stuyver L,Johnson M,Merle P,Abidi H,Trépo C,Zoulim F
Evidence	Sequence alignment andcomparison with consensus sequence predicted for each ge-notype13also showed a 100% homology by comparison withHBV genotype A consensus polymerase sequence in patient10 and a Q474H variant between domain A and B in patient 4.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation